Research Activities

Research of the Lüning Group

Key Words: Supramolecular Chemistry, Molecular Recognition

 

Collaborative Research Centres 677 - Function by Switching

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Marie Curie Academic-Industrial Initial Training Network on Dynamic Molecular Nanostructures

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DFG Priority Program 1362: Porous Metal-Organic Frameworks

Within the priority program 1362 "Porous Metal-Organic Frameworks" in the consortium "Targeting selective host-guest interactions in functionalized MOFs - synthesis, NMR studies and sensor design", five research groups from inorganic chemistry (Stock, Bein, Lotsch), NMR (Senker) and organic chemistry (Lüning) cooperate to place new functional groups into the porous interior of MOFs, to characterize them, and to test them in new applications. Our contribution is twofold. New organic linkers for MOFs are synthesized, but also resulting MOFs shall be modified post-synthetically.

 

Concave Reagents

The high selectivity of enzymatic reactions is largely caused by the concave shielding of the active site. Therefore, we introduce reagents and catalysts into bimacrocyclic compounds in such a way that the functional groups are pointing towards the inside. Their shielding by the macrocycle leads to increased selectivities. We study respective acid, base or transition metal catalyzed reactions, e. g. the Cu(I) catalyzed cyclopropanation. Current projects deal with bifunctional acid/base catalysis and organocatalysis by N-heterocyclic carbenes (NHC).

All publications for Concave Reagents are numbered consecutively in the list of literature, e.g. Concave Reagents 66.

 

Multiple Hydrogen Bonds

Due to the anisotropy of a hydrogen bond, an array of several hydrogen bonds stores information. Large binding constants are found for complementary partners. We develop new hydrogen bond patterns, e. g. by placing four hydrogen bond donors D and acceptors A side by side, e. g. DAAD - ADDA. The recognition between partly matching or non-matching patterns is inferior, orthogonal recognition is observed.

All publications for Multiple Hydrogen Bonds are numbered consecutively in the list of literature, e.g. Multiple Hydrogen Bonds 10.

 

Dynamic Combinatorial Synthesis

Dynamical Combinatorial Chemistry is characterized by the fact that a large number of molecules exist in equilibrium with one another facilitated by a reversible reaction. If a suitable template is added to this dynamical mixture, which stabilizes one of the products with respect to the other members of the library, all other products will be converted to the stabilized product. We exploit the template effect in dynamic combinatorial libraries to synthesize macrocycles using metal ions as templates combined with imine formation as macrocyclization reaction, or by using organic templates.

All publications for Dynamic Combinatorial Synthesis are numbered consecutively in the list of literature, e.g. Dynamic Combinatorial Chemistry 8.

 

Supramolecular Chemistry (Optional Course)

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pdf-version of "Supramolecular Chemistry and Molecular Recognition"